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Cannabinoid receptor gene polymorphisms and cognitive performance in patients with schizophrenia and controls
Ferretjans, Rodrigo; de Souza, Renan P.; Panizzutti, Bruna; Ferrari, Pâmela; Mantovani, Lucas; de Campos-Carli, Salvina M.; Santos, Rafael R.; Guimarães, Fernanda C.; Teixeira, Antonio L.; Gama, Clarissa S.; Salgado, João V..
Affiliation
  • Ferretjans, Rodrigo; Universidade Federal de Minas Gerais (UFMG). Instituto de Ciências Biológicas. Programa Interdisciplinar de Pós-Graduação em Neurociências. Belo Horizonte. BR
  • de Souza, Renan P.; UFMG. Instituto de Ciências Biológicas. Programa de Pós-Graduação em Genética. Belo Horizonte. BR
  • Panizzutti, Bruna; Deakin University. The Institute for Mental and Physical Health and Clinical Translation. Barwon Health. AU
  • Ferrari, Pâmela; Universidade Federal do Rio Grande do Sul (UFRGS). Programa de Pós-Graduação em Psiquiatria e Ciências do Comportamento (PPGPSIQ). Porto Alegre. BR
  • Mantovani, Lucas; Universidade Federal de Minas Gerais (UFMG). Instituto de Ciências Biológicas. Programa Interdisciplinar de Pós-Graduação em Neurociências. Belo Horizonte. BR
  • de Campos-Carli, Salvina M.; Universidade Federal de Minas Gerais (UFMG). Instituto de Ciências Biológicas. Programa Interdisciplinar de Pós-Graduação em Neurociências. Belo Horizonte. BR
  • Santos, Rafael R.; Universidade Federal de Minas Gerais (UFMG). Instituto de Ciências Biológicas. Programa Interdisciplinar de Pós-Graduação em Neurociências. Belo Horizonte. BR
  • Guimarães, Fernanda C.; Universidade Federal de Minas Gerais (UFMG). Instituto de Ciências Biológicas. Programa Interdisciplinar de Pós-Graduação em Neurociências. Belo Horizonte. BR
  • Teixeira, Antonio L.; Santa Casa BH. Instituto de Ensino e Pesquisa. Belo Horizonte. BR
  • Gama, Clarissa S.; Deakin University. School of Medicine. Centre for Molecular and Medical Research. Geelong. AU
  • Salgado, João V.; Universidade Federal de Minas Gerais (UFMG). Instituto de Ciências Biológicas. Programa Interdisciplinar de Pós-Graduação em Neurociências. Belo Horizonte. BR
Braz. J. Psychiatry (São Paulo, 1999, Impr.) ; Braz. J. Psychiatry (São Paulo, 1999, Impr.);44(1): 26-34, Jan.-Feb. 2022. tab
Article in En | LILACS-Express | LILACS | ID: biblio-1360175
Responsible library: BR1.1
ABSTRACT

Objective:

To test the hypothesis that genetic variations of cannabinoid receptors contribute to the pathophysiology of cognitive deficits in schizophrenia.

Methods:

In this genetic association case-control study, cannabinoid receptor polymorphisms CNR1 rs12720071 and CNR2 rs2229579 were tested for association with neurocognitive performance in 69 patients with schizophrenia and 45 healthy controls. Neurocognition was assessed by the Brief Assessment of Cognition in Schizophrenia (BACS).

Results:

We found a consistent association between CNR1 rs12720071 polymorphism and the cognitive performance of patients in several cognitive domains. Patients with C/C polymorphism presented significantly worse performance in motor speed, verbal fluency, attention/processing speed and reasoning/problem solving.

Conclusion:

Although limited, our data support the hypothesis that CNR1 variations may be associated with the pathogenesis of cognitive deficits of schizophrenia.
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Full text: 1 Collection: 01-internacional Database: LILACS Type of study: Observational_studies / Risk_factors_studies Language: En Journal: Braz. J. Psychiatry (São Paulo, 1999, Impr.) Journal subject: PSIQUIATRIA Year: 2022 Document type: Article Affiliation country: / Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: LILACS Type of study: Observational_studies / Risk_factors_studies Language: En Journal: Braz. J. Psychiatry (São Paulo, 1999, Impr.) Journal subject: PSIQUIATRIA Year: 2022 Document type: Article Affiliation country: / Country of publication: